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Your Position: Home > Glycoprotein (NiV, HeV)

Glycoprotein (NiV, HeV)

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Cat. No. Species Product Description Structure Purity Feature
GLN-N52H3 Nipah virus Nipah virus Glycoprotein G, His Tag (MALS verified)
GLN-N52H3-structure
GLN-N52H3-sds
GLN-H52H3 Hendra virus Hendra virus Glycoprotein, His Tag (MALS verified)
GLN-H52H3-structure
GLN-H52H3-sds
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Part of Bioactivity data

GLN-N52H3-SPR
 Glycoprotein (NiV, HeV) SPR

Anti-Nipah/Hendra Glycoprotein G Antibody, Human IgG1 captured on Protein A Chip can bind Nipah virus Glycoprotein G, His Tag (Cat. No. GLN-N52H3) with an affinity constant of 0.188 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

GLN-H52H3-SPR
 Glycoprotein (NiV, HeV) SPR

Anti-Nipah/Hendra Glycoprotein G Antibody, Human IgG1 captured on Protein A Chip can bind Hendra virus Glycoprotein, His Tag (Cat. No. GLN-H52H3) with an affinity constant of 12.3 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Synonym Name

Glycoprotein

Background

Hendra virus (HeV) and Nipah virus (NiV) are henipaviruses discovered in the mid-to late 1990s that possess a broad host tropism and are known to cause severe and often fatal disease in both humans and animals. HeV and NiV infect host cells through the coordinated efforts of two envelope glycoproteins. The G glycoprotein attaches to cell receptors, triggering the fusion (F) glycoprotein to execute membrane fusion. G is a type II homotetrameric transmembrane protein responsible for binding to ephrinB2 or ephrinB3 (ephrinB2/B3) receptors. F is a homotrimeric type I transmembrane protein that is synthesized as a premature F0 precursor and cleaved by cathepsin L during endocytic recycling to yield the mature, disulfide-linked, F1 and F2 subunits. Upon binding to ephrinB2/B3, NiV G undergoes conformational changes leading to F triggering and insertion of the F hydrophobic fusion peptide into the target membrane. Subsequent refolding into the more stable post-fusion F conformation drives merger of the viral and host membranes to form a pore for genome delivery to the cell cytoplasm.

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